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4,000 m2 stem cell facility to be built at Leiden Bio Science Park by LUMC

Leiden Bio Science Park- invest in rotterdam - the-hagueregenerative medicine stem cell therapy

Leiden University Medical Center (LUMC) is building the largest non-profit stem cell and gene therapy facility in the Netherlands, and one of the largest facilities in Europe. In the ‘NECSTGEN’ facility, the Netherlands Centre for the Clinical advancement of Stem Cell and Gene Therapies, research will be conducted in the field of regenerative medicine; medicine that restores or replaces diseased cells, tissues and organs. In NECSTGEN, researchers are working on the breakthroughs of the future, such as insulin-producing cells grown on demand for diabetes patients.

Only very limited affordable, non-profit locations are available worldwide, where product development of the latest generation of regenerative medical treatments is stimulated and facilitated. Researchers often get stuck when they want to take their scientific discovery from the laboratory to the clinic. The NECSTGEN is needed to test and scale up breakthroughs and make them applicable to patients quicker.

The NECSTGEN is a public-private partnership: researchers and startups from all over Europe and beyond will soon be welcomed in Leiden to accelerate the application of these therapies. The NECSTGEN is an important new asset for the local ecosystem in biotechnology. The past few months have shown that this type of development is called for.

Cells grown on demand

Everyone can benefit from developments in regenerative medicine, says LUMC Professor Ton Rabelink: “Currently, patients with chronic conditions such as cardiovascular disease, kidney failure or diabetes are being treated for years. This is intense for the patient and costly for society. In the future, we can treat patients with their own cells, with gene therapy or tissue manipulation. For example, insulin-producing cells grown on demand to combat diabetes, specially made for your body”. Hundreds of thousands of chronically ill people benefit from such breakthroughs. It also reduces the sharply rising cost of care if patients can be cured in the future with a one-time treatment.

4,000 square meters

The NECSTGEN will be realised in Mirai house located at the largest Life Science and Health cluster in the Netherlands, the Leiden Bio Science Park of which the LUMC is also part. Researchers and startups can turn to the NECSTGEN for the research and development of stem cell and gene therapy products. The Good Manufacturing Practice (GMP) facility will contain 8 class B spaces, 2 class C spaces, and a QC laboratory. The NECSTGEN measures 4,000 square metres in total. Here, academic discoveries will be translated locally into scalable therapies for patients, even for conditions that affect only a small group of patients (called orphan diseases).

International cooperation

The NECSTGEN is part of the collaboration with the Canadian Centre for Commercialisation of Regenerative Medicine (CCRM), which realised a similar facility in Toronto. In addition, the NECSTGEN contributes to RegMed XB (Regenerative Medicine Crossing Borders), a public-private partnership of Dutch and Flemish partners.

The LUMC is discussing additional subsidies and investments for the NECSTGEN with the Leiden University, the province of Zuid-Holland, the municipality of Leiden, ministries and health funds. At the end of 2021 NECSTGEN will be opened for researchers and startups.

For more information please visit necstgen.com.

Lissa Boxy ruit

Lissa Culbertson Boxy

Senior Account Manager Life Sciences & Health